Pigment particle's life-cycle

When the pigment particle enters the skin, there is always traumatization that initiates the innate Immunogenic Response. After that, the five most common scenarios happen to the pigment particle. Immediate Phagocytosis and Migration to the Lymphatic System: Upon skin penetration, innate immune mechanisms are triggered, and pigment particles may be swiftly engulfed by phagocytes - primarily macrophages, and transported to the lymphatic system for further processing or permanent residence. Migration and Reaching the Hypodermis or Blood Vessels. Particles that bypass initial phagocytic capture can inadvertently migrate to the hypodermis or, less commonly, into capillaries. Particles in the hypodermis may persist...